BDBM178100 BRD3308::US11377423, Cmpd 1

SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1ccc(F)cc1N

InChI Key InChIKey=RRJDFENBXIEAPD-UHFFFAOYSA-N

Data  3 KI  31 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 178100   

TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178100(BRD3308 | US11377423, Cmpd 1)
Affinity DataKi:  29nM ΔG°:  -10.3kcal/mole IC50:  64nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178100(BRD3308 | US11377423, Cmpd 1)
Affinity DataIC50:  64nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178100(BRD3308 | US11377423, Cmpd 1)
Affinity DataIC50:  64nMAssay Description:Inhibition of recombinant human full length HDAC3 using FAM-labeled acetylated peptide A as substrate preincubated for 3 hrs followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178100(BRD3308 | US11377423, Cmpd 1)
Affinity DataIC50:  68nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178100(BRD3308 | US11377423, Cmpd 1)
Affinity DataIC50:  64nMAssay Description:Inhibition of human recombinant HDAC3 at 0.5 uM using AMC-K(Ac)GL as substrate incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178100(BRD3308 | US11377423, Cmpd 1)
Affinity DataIC50:  68nMMore data for this Ligand-Target Pair
In DepthDetails US Patent